Köhler and Milstein Publish the Hybridoma Method
MRC Laboratory of Molecular Biology (LMB), Francis Crick Avenue, Trumpington, Cambridge, Cambridgeshire, Cambridgeshire and Peterborough, England, CB2 0QH, United Kingdom
MRC Laboratory of Molecular Biology
CONFIRMED88% CONFIDENCENature's[1] own page for the article gives citation_online_date 1975/08/01 and shows "01 August 1975" as the publication date, with the paper received 14 May 1975 and accepted 26 June 1975; it is Nature volume 256, issue 5517, pages 495-497.
Georges Köhler and César Milstein report in Nature that fusing an antibody-producing cell with a myeloma cell yields a line that secretes a single antibody indefinitely. Monoclonal antibodies become the basis of the modern biologics industry.
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