Pins matching tag:Obesity

On 5 December 2017 the US FDA approved Ozempic (semaglutide 0.5 mg and 1 mg, once weekly) for adults with type 2 diabetes, the first brand in the semaglutide line that later produced Wegovy and the Wegovy pill.

On 4 June 2021 the US FDA approved Wegovy (semaglutide 2.4 mg once weekly) for chronic weight management, the first new weight drug since 2014, with 12.4% average weight loss over placebo in adults without diabetes.

On 8 November 2023 the US FDA approved Zepbound (tirzepatide, once weekly) for chronic weight management, with 18% average weight loss at 15 mg over 72 weeks, setting up the Wegovy versus Zepbound rivalry.

On 27 August 2024 Lilly began selling 2.5 mg and 5 mg Zepbound vials to self-paying patients through LillyDirect at US$399 and US$549 for a four-week supply.

On 26 November 2024 Amgen reported 52-week Phase 2 data for its monthly obesity candidate MariTide, with up to about 20% average weight loss without a plateau, and announced the MARITIME Phase 3 program.

On 29 July 2025 Novo Nordisk appointed Maziar Mike Doustdar, head of International Operations, as president and CEO from 7 August 2025, succeeding Lars Fruergaard Jørgensen after 34 years with the company.

On 10 September 2025 Novo Nordisk announced it intends to cut about 9,000 of its 78,400 jobs worldwide, around 5,000 of them in Denmark, to save about DKK 8 billion a year by the end of 2026.

On 13 November 2025 Pfizer completed its acquisition of obesity biotech Metsera for US$65.60 per share in cash, an enterprise value of about US$7.0 billion, plus a contingent value right of up to US$20.65 per share.

Eli Lilly's market value crossed $1 trillion on 21 November 2025, making it the first drugmaker and first health-care company to join the club dominated by tech giants. Its shares hit a record $1,066.65 and closed at $1,059.70, driven by Zepbound and Mounjaro.

On 22 December 2025 the US FDA approved the once-daily Wegovy pill (oral semaglutide 25 mg), the first oral GLP-1 for weight management, which showed 16.6% mean weight loss in the OASIS 4 trial.

On 19 March 2026 the US FDA approved Wegovy HD (semaglutide 7.2 mg, once weekly) for weight loss after the STEP UP trial showed 20.7% mean weight loss, the first GLP-1 approval under the FDA's priority voucher pilot.

The FDA approved Eli Lilly's Foundayo, a once-daily GLP-1 pill for weight loss that needs no food or water restrictions, with direct-to-consumer sales from April 6.

People on the top 12 mg dose of Lilly's triple-hormone shot retatrutide lost an average of 28.3% of their body weight (70.3 lbs) over 80 weeks, and 30.3% by two years in the extension - weight loss at the level of bariatric surgery.

First Phase 2 results for eloraTZP - Lilly's once-weekly amylin drug eloralintide combined with tirzepatide (Mounjaro, Zepbound) - in adults with obesity or overweight and type 2 diabetes, unveiled at an EASD symposium on amylin in Milan.

Lilly plans to file its Biologics License Application for retatrutide, the triple-hormone obesity shot that cut weight by up to 28.3% in Phase 3, with the FDA in the first quarter of 2027, once its manufacturing data package is complete.

Amgen's phase 3 trial of Maridebart Cafraglutide in obesity reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 3,200 participants. The primary objective of this trial is to evaluate the long-term efficacy, safety, and tolerability of maridebart cafraglutide in participants with obesity or overweight. Trial 20250197 is an extension of trial 20210181 (NCT06858839).

Novo Nordisk's phase 3 trial of Cagrisema in obesity reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 2,500 participants. This clinical study is testing how the study medicine CagriSema helps people living with obesity, with or without type 2 diabetes (T2D), lose weight. The purpose of the study is to find out how safe and effective CagriSema is for body weight loss in these participants. Participants will receive either CagriSema or semaglutide, and which treatment participants receive is decided by chance. CagriSema is a new study medicine being tested, while semaglutide is a medicine that doctors can already prescribe.

Amgen's phase 3 trial of Maridebart Cafraglutide in atherosclerotic cardiovascular disease reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 12,800 participants. The primary objective of this trial is to demonstrate that maridebart cafraglutide is superior to placebo when given as an adjunct to standard of care with respect to reducing cardiovascular (CV) morbidity and mortality.

Amgen's phase 3 trial of Maridebart Cafraglutide in heart failure with preserved ejection fraction reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 5,056 participants. This trial will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascular (CV) deaths and improvement in HF symptoms in participants with HF with preserved ejection fraction (HFpEF) and HF with mildly reduced ejection fraction (HFmrEF) who are obese. This is a phase 3, global, multicenter, 2-part trial with a double-blind period and an open-label extension (OLE). The trial is event-driven, and Part 1 will conclude when approximately 850 primary endpoint events have occurred.