Chronopin: upcoming release dates, events and other important dates

The inbound half of LAX's 4.4-mile roadway rebuild, which separates airport traffic from Sepulveda Boulevard and neighbourhood streets, is due in May 2028, two months before the Games.

Victoria's largest road project, burying the missing link in Melbourne's ring road in twin three-lane tunnels. Estimated date.

An elevated 24 km driverless line, the first metro for a capital that has debated building one since the 1940s. Estimated date.

The United Kingdom and Ireland co-host the European Championship across nine stadiums. Estimated date.

GSK's phase 3 trial of MRNA Seasonal Flu Vaccine in influenza, human reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 54,000 participants. This study will compare an investigational mRNA flu vaccine with a licensed flu vaccine in adults 65 years of age and older. Participants will receive one injection and will be followed during the flu season. The study will measure prevention of laboratory-confirmed flu illness, side effects, and immune responses.

Amgen's phase 3 trial of Maridebart Cafraglutide in heart failure with preserved ejection fraction reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 5,056 participants. This trial will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascular (CV) deaths and improvement in HF symptoms in participants with HF with preserved ejection fraction (HFpEF) and HF with mildly reduced ejection fraction (HFmrEF) who are obese. This is a phase 3, global, multicenter, 2-part trial with a double-blind period and an open-label extension (OLE). The trial is event-driven, and Part 1 will conclude when approximately 850 primary endpoint events have occurred.

Amgen's phase 3 trial of Maridebart Cafraglutide in atherosclerotic cardiovascular disease reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 12,800 participants. The primary objective of this trial is to demonstrate that maridebart cafraglutide is superior to placebo when given as an adjunct to standard of care with respect to reducing cardiovascular (CV) morbidity and mortality.

A nuclear-powered rotorcraft that will fly between sites on Saturn's moon Titan, arriving in the 2030s. Scheduled date.

AstraZeneca's phase 3 trial of Elecoglipron in type 2 diabetes mellitus reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 2,000 participants. The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron and dapagliflozin in combination, compared with elecoglipron alone and dapagliflozin alone, in adults with type 2 diabetes mellitus (T2DM) inadequately managed with lifestyle management alone or treated with other background glucose-lowering medication.

Los Angeles hosts its third Games after 1932 and 1984, using almost entirely existing venues.

Los Angeles is preparing to host the 2028 Summer Olympics with zero new venues and a 'no-car' transit plan, a bold bet for a city not known for its public transport.

Totality passes directly over central Sydney for nearly four minutes, the first there since 1857.

Roche's phase 3 trial of Enicepatide in obesity or overweight reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 2,000 participants. The purpose of this study is to assess the efficacy and safety of enicepatide, a dual glucagon like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist (RA), at multiple doses compared with placebo for weight management in participants without Type 2 diabetes mellitus (T2DM) who have obesity or overweight with at least one weight-related comorbidity.

AstraZeneca's phase 3 trial of Elecoglipron in weight management reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 4,500 participants. This master study protocol, Study D7260C00015, covers 2 independent, pivotal studies, Study 1 and Study 2. Each study is a global, randomized, double-blind, parallel-group, multicenter, Phase III study to assess the efficacy and safety of elecoglipron compared with placebo adjunct to diet and exercise for weight management, in adults living with obesity or overweight with at least one weight-related comorbidity, and without T2DM (Study 1) or with T2DM (Study 2).

The five-year UPS-Teamsters agreement covering some 340,000 workers expires on 31 July 2028, and the union's president has already said a strike is coming.

AstraZeneca's phase 3 trial of AZD6234 in obesity or overweight reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 2,500 participants. The study will evaluate how well AZD6234 works and how safe it is in adults with excess weight or obesity.

The 2028 Summer Paralympics, also known as the Los Angeles 2028 Summer Paralympic Games, and branded as LA28, will be the 18th edition of the Summer Paralympic Games, an international multi-sport parasports event governed by the International Paralympic Committee. The Games are scheduled to take place from August 15 to August 27, 2028, in Los Angeles, California, United States. The pin sits at Los Angeles Memorial Coliseum.

Boehringer Ingelheim's phase 3 trial of BI 690517 in kidney disease, chronic reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 11,000 participants. This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). People who already take empagliflozin or any other sodium-glucose cotransporter-2 inhibitor (SGLT2i) can also join. The study is also open to people who currently do not take any of these treatments. The purpose of this study is to find out whether a medicine called BI 690517 helps people with chronic kidney disease when taken in combination with a study medicine called empagliflozin. Worsening of kidney function increases the risk for kidney failure, cardiovascular disease, and heart failure hospitalisation.

Saudi Arabia's Jeddah Tower has passed its 100th floor and is on track to become the world's tallest building, edging past a kilometre in height once its spire is counted.

Time Out brings its market home to the city where the magazine started in 1968: 26,400 square feet over three floors at 10 Piccadilly, on a long-term partnership with The Crown Estate, as the flagship of the whole portfolio.

Cancer, liver-disease and pregnancy warnings become mandatory on every alcohol container sold in Ireland, after the government pushed the start from 22 May 2026 to 3 September 2028 citing economic circumstances.