Chronopin: upcoming release dates, events and other important dates

Microsoft's consumer Extended Security Updates programme for Windows 10 22H2 delivers its last security patches. A home Windows 10 PC keeps working after this date but gets no more security fixes, and 12 October 2027 is also the last day anyone can enrol.

Merck & Co.'s phase 3 trial of MK-8527 in human immunodeficiency virus reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 4,580 participants. Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection.

Argentines choose a president and renew Congress on 24 October 2027, the first presidential election since Javier Milei's 2023 win.

Austin's purpose-built circuit opens with a blind 40-metre climb into a hairpin, and borrows corners from Silverstone, Istanbul and Hockenheim.

The FOMC announces its rate decision on the second day of its October 26-27 2027 meeting. On 21 September 2026 Kalshi last traded Fed maintains rate 54%, Hike 25bps 46%, Cut 25bps 7%.

A five-kilometre SkyTrain extension meant to unlock a taller, denser Broadway Corridor in Vancouver has slipped from its original early-2026 target to autumn 2027.

At 2,200 metres above sea level the air is thin enough to change how the cars cool, brake and make power, and the lap ends through a baseball stadium.

The Bureau of Meteorology's official tropical cyclone season for the Australian region runs from 1 November to 30 April. An average season brings 10 cyclones, three or four of which cross the coast.

All 13 Boston City Council seats, nine district and four at-large, are up for their regular two-year election, the first test of the council after Wu's re-election.

AstraZeneca's phase 3 trial of Tozorakimab in viral lung infection and acute respiratory failure reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 3,527 participants. The purpose of this study is to evaluate the effect of tozorakimab, as an add-on to SoC in patients with viral lung infection requiring supplemental oxygen, on the prevention of death or progression to IMV/ECMO.

Interlagos runs anticlockwise over a hillside, is short enough to bunch the field, and has decided more championships late than anywhere else.

The only race Formula 1 runs on a Saturday night, straight down the Strip past the casinos at close to 350 km/h.

Frozen 3 is an upcoming American animated musical fantasy film written and directed by Jennifer Lee. Produced by Walt Disney Animation Studios, it is the third feature film in the Frozen franchise, following Frozen II.

Microsoft's next Xbox, Project Helix, uses a custom AMD chip with Zen 6 cores and RDNA 5 graphics; Microsoft has given no release date, with reports pointing to late 2027 and developer alpha hardware in 2027.

The 32nd UN climate conference is held in Addis Ababa in November 2027, the first COP in sub-Saharan Africa in sixteen years, with the African Group holding the presidency.

A new COASTER commuter-rail platform on Harbor Drive between 1st and 5th Streets, by the Gaslamp Quarter, the convention centre and Petco Park, with San Diego Trolley connections either side. The $33 million project also adds a pocket track so trains can run more often.

Line 19 will run 46.2 km with 34 stations from Baoshan Railway Station to Hongjian Road through six districts, built to ease traffic on Pudong South Road and crowding on the southern end of line 8 and the northern ends of lines 1 and 3. The northern section from Baoshan Railway Station to Yierba Jinian Road comes first; the southern section follows in 2029 and the middle section in 2031.

AstraZeneca's phase 3 trial of BGF MDI 320/14.4/9.6 μG in copd reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 5,000 participants. This study will evaluate the effect of triple ICS/LAMA/LABA therapy with BGF MDI 320/14.4/9.6 μg on cardiopulmonary outcomes relative to LAMA/LABA therapy with GFF MDI 14.4/9.6 μg in a population with COPD and elevated cardiopulmonary risk.

The penultimate round runs at night at Lusail, a fast, flowing circuit built for MotoGP and hard on tyres.

The FOMC announces its rate decision on the second day of its December 7-8 2027 meeting. The meeting is one of the four in 2027 that comes with a Summary of Economic Projections - the "dot plot" - and a press conference. On 21 September 2026 Kalshi last traded Fed maintains rate 73%, Cut 25bps 13%, Hike 25bps 6%.

Every obligation the Cyber Resilience Act carries comes into force: products with digital elements may only be placed on the EU market if they meet the Act's essential cybersecurity requirements, carry a conformity assessment and are supported with security updates for their declared support period.

The season ends at Yas Marina as the sun sets, and for the first time the finale is a Sprint weekend too.

The Lord of the Rings: The Hunt for Gollum is an upcoming fantasy film directed by Andy Serkis, written by Fran Walsh, Philippa Boyens, Phoebe Gittins, and Arty Papageorgiou, and based on characters created by J. R. R. Tolkien.

Avengers: Doomsday and Avengers: Secret Wars are American superhero films based on the Marvel Comics superhero team the Avengers, produced by Marvel Studios and distributed by Walt Disney Studios Motion Pictures. They are respectively the fifth and sixth installments in the Avengers film series following Avengers: Endgame (2019), and the 39th and 40th films of the Marvel Cinematic Universe (MCU).

The 24-month reinforced health monitoring the Gard prefect imposed on Perrier's Romaine VI and VII boreholes runs out, and Nestlé must then show the spring's original purity and stable mineral content to keep its natural mineral water status.

Section 3 completes the nine-mile D Line extension with 2.56 miles and stations at Westwood/UCLA and Westwood/VA Hospital, putting the subway within reach of UCLA before the 2028 Olympics.

Amgen's phase 3 trial of Maridebart Cafraglutide in obesity reaches primary completion, the point at which the last participant's primary outcome is measured. The trial enrolled 3,200 participants. The primary objective of this trial is to evaluate the long-term efficacy, safety, and tolerability of maridebart cafraglutide in participants with obesity or overweight. Trial 20250197 is an extension of trial 20210181 (NCT06858839).

Wall-mounted vertical turntable designed by a collective of former Apple engineers.